Invention Grant
- Patent Title: pH sensitive prodrugs of 2,6-diisopropylphenol
- Patent Title (中): 2,6-二异丙基苯酚的pH敏感前药
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Application No.: US11881143Application Date: 2007-07-24
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Publication No.: US07691904B2Publication Date: 2010-04-06
- Inventor: Subramanian Marappan , Cris Davenport , Sepehr Sarshar
- Applicant: Subramanian Marappan , Cris Davenport , Sepehr Sarshar
- Applicant Address: US CA Vista
- Assignee: Auspex Pharmaceuticals, Inc
- Current Assignee: Auspex Pharmaceuticals, Inc
- Current Assignee Address: US CA Vista
- Agent Dennis A. Bennett; Michael Sertic
- Main IPC: A61K31/165
- IPC: A61K31/165 ; A61K31/216 ; C07C233/02 ; C07C69/712
Abstract:
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
Public/Granted literature
- US20080248093A1 pH sensitive prodrugs of 2,6-diisopropylphenol Public/Granted day:2008-10-09
Information query
