Invention Grant
- Patent Title: Chemical linkers and conjugates thereof
- Patent Title (中): 化学接头及其共轭物
-
Application No.: US11134826Application Date: 2005-05-19
-
Publication No.: US07691962B2Publication Date: 2010-04-06
- Inventor: Sharon E. Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Killian Horgan , Zhi-Hong Li , Bilal Sufi
- Applicant: Sharon E. Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Killian Horgan , Zhi-Hong Li , Bilal Sufi
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Darby & Darby PC
- Main IPC: C07K2/00
- IPC: C07K2/00 ; A61K38/00
Abstract:
The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
Public/Granted literature
- US20060024317A1 Chemical linkers and conjugates thereof Public/Granted day:2006-02-02
Information query
