Invention Grant
US07691976B2 BRAF35 protein and BRCA2/BRAF35 complex and methods of use
失效
BRAF35蛋白和BRCA2 / BRAF35复合物及其使用方法
- Patent Title: BRAF35 protein and BRCA2/BRAF35 complex and methods of use
- Patent Title (中): BRAF35蛋白和BRCA2 / BRAF35复合物及其使用方法
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Application No.: US10416387Application Date: 2001-11-13
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Publication No.: US07691976B2Publication Date: 2010-04-06
- Inventor: Ramin Shiekhattar
- Applicant: Ramin Shiekhattar
- Applicant Address: US PA Philadelphia
- Assignee: The Wistar Institute
- Current Assignee: The Wistar Institute
- Current Assignee Address: US PA Philadelphia
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US01/47101 WO 20011113
- International Announcement: WO02/38795 WO 20020516
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C07K17/00 ; A61K38/16 ; G01N33/00 ; G01N1/00 ; G01N1/18
Abstract:
An isolated nucleic acid sequence of BRAF35 and polypeptides encoded thereby are provided, as well as a multiprotein complex, and an antibody capable of binding selectively to the BRAF35 protein. Related agents and compositions which modulate interaction between BRCA2 and BRAF35 and methods of their use for screening for the BRCA2 protein, suppressing tumors and identifying DNA damage in cells indicative of a risk for developing cancer are also provided.
Public/Granted literature
- US20040053347A1 Braf35 protein and brca2/braf35 complex and methods of use Public/Granted day:2004-03-18
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