Invention Grant
US07691980B2 Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
有权
通过混合模式色谱法在水溶性非离子有机聚合物存在下增强抗体的能力和纯化
- Patent Title: Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
- Patent Title (中): 通过混合模式色谱法在水溶性非离子有机聚合物存在下增强抗体的能力和纯化
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Application No.: US11970296Application Date: 2008-01-07
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Publication No.: US07691980B2Publication Date: 2010-04-06
- Inventor: Peter S. Gagnon
- Applicant: Peter S. Gagnon
- Applicant Address: US CA Hercules
- Assignee: Bio-Rad Laboratories, Inc.
- Current Assignee: Bio-Rad Laboratories, Inc.
- Current Assignee Address: US CA Hercules
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/00 ; C07K1/22
Abstract:
This invention relates to the use of mixed mode chromatography for purification of at least one intact non-aggregated antibody from a mixture containing intact non-aggregated antibodies and undesirable materials, including fragmented or aggregated antibodies, host cell proteins, DNA, endotoxin, and/or virus. This invention further relates to the integration of such a method into a multi-step procedure with other fractionation methods for purification of antibodies suitable for in vivo applications.
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