Invention Grant
- Patent Title: Nucleic acids encoding the human ALEX1 protein
- Patent Title (中): 编码人ALEX1蛋白的核酸
-
Application No.: US10204751Application Date: 2001-02-23
-
Publication No.: US07691992B2Publication Date: 2010-04-06
- Inventor: Igor V. Kurochkin , Natsumi Yonemitsu
- Applicant: Igor V. Kurochkin , Natsumi Yonemitsu
- Applicant Address: JP Kita-Ku, Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Kita-Ku, Tokyo
- Agency: Morrison & Foerster LLP
- Priority: JP2000-054466 20000225
- International Application: PCT/JP01/01373 WO 20010223
- International Announcement: WO01/62916 WO 20010830
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07H21/02 ; C07H21/04 ; C12P21/00 ; C12N1/00 ; C12N15/00 ; C12N15/09
Abstract:
The present invention provides a novel protein containing an armadillo repeat, a gene encoding this protein, and production and use thereof. The present inventors identified a gene named ALEX1 encoding a human-derived novel armadillo repeat-containing protein. It was clarified that ALEX1 interacts with several proteins including insulin-degrading enzyme, presenilin-1, and JNK interacting protein 1. This gene shows significantly decreased expression in cancer cells. The protein ALEX1 and the gene encoding this protein are usable as tools in testing for diseases such as cancer and Alzheimer's disease and developing pharmaceutical agents.
Public/Granted literature
- US20040038212A1 Novel armadillo repeat-containing protein alex1 Public/Granted day:2004-02-26
Information query
