Invention Grant
US07691994B2 Compositions and methods for the detection of human T cell receptor variable family gene expression
失效
用于检测人T细胞受体可变家族基因表达的组合物和方法
- Patent Title: Compositions and methods for the detection of human T cell receptor variable family gene expression
- Patent Title (中): 用于检测人T细胞受体可变家族基因表达的组合物和方法
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Application No.: US10612121Application Date: 2003-07-02
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Publication No.: US07691994B2Publication Date: 2010-04-06
- Inventor: Jamie L. Brewer , Solveig G. Ericson
- Applicant: Jamie L. Brewer , Solveig G. Ericson
- Agency: Steptoe & Johnson PLLC
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
Compositions and methods for the assessment of T cell receptor variable subunits. The present invention provides nucleotide sequences for the evaluation of the expression of TCRV families. These nucleotides sequences were obtained through a bioinformatic investigation of the nucleotide sequences for TCRVα and TCRVβ families. The nucleotide sequences of the present invention uniquely recognize each and every subfamily and allelic member of a particular TCRV family, while at the same time not recognizing the members of any other TCRV family. This unique expression recognition profile of the nucleotide sequences of the present invention provides great utility for the assessment of TCR families in a clinical setting, such as through polymerase chain reactions, gene chip technology, and direct electrophoretic measurement of DNA or RNA.
Public/Granted literature
- US20040014127A1 Compositions and methods for the detection of human T cell receptor variable family gene expression Public/Granted day:2004-01-22
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