Invention Grant
- Patent Title: Three component chimeric antisense oligonucleotides
- Patent Title (中): 三组分嵌合反义寡核苷酸
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Application No.: US11035693Application Date: 2005-01-14
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Publication No.: US07691996B2Publication Date: 2010-04-06
- Inventor: Amy Arrow , Roderic M. K. Dale , Tod Mitchell Woolf
- Applicant: Amy Arrow , Roderic M. K. Dale , Tod Mitchell Woolf
- Applicant Address: US FL Sarasota US MA Natick
- Assignee: Lakewood-Amedex,Sequitur, Inc.
- Current Assignee: Lakewood-Amedex,Sequitur, Inc.
- Current Assignee Address: US FL Sarasota US MA Natick
- Agency: Mintz, Levin, Cohen, Ferris, Glovsky and Popeo P.C.
- Agent Ingrid A. Beattie
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07H21/02 ; C07H21/04
Abstract:
This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3′ and 5′ ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
Public/Granted literature
- US20050202541A1 Three component chimeric antisense oligonucleotides Public/Granted day:2005-09-15
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