Invention Grant
- Patent Title: Penicillin crystals and process for producing the same
- Patent Title (中): 青霉素晶体及其生产方法
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Application No.: US10574278Application Date: 2004-10-08
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Publication No.: US07692003B2Publication Date: 2010-04-06
- Inventor: Isao Wada , Yutaka Kameyama
- Applicant: Isao Wada , Yutaka Kameyama
- Applicant Address: unknown Osaka-shi JP Tokyo
- Assignee: Otsuka Chemical Co., Ltd.,Taiho Pharmaceutical Co., Ltd.
- Current Assignee: Otsuka Chemical Co., Ltd.,Taiho Pharmaceutical Co., Ltd.
- Current Assignee Address: unknown Osaka-shi JP Tokyo
- Agency: Kratz, Quintos & Hanson, LLP
- Priority: JP2003-350406 20031009
- International Application: PCT/JP2004/015305 WO 20041008
- International Announcement: WO2005/035539 WO 20050421
- Main IPC: C07D477/14
- IPC: C07D477/14
Abstract:
The present invention provides 2β-chloromethyl-2α-methylpenam-3α-carboxylic acid benzhydryl ester (CMPB) crystals of excellent stability, and a process for producing the CMPB crystals comprising the steps of (A) concentrating a solution containing CMPB; (b) subjecting the thus-obtained concentrate to column chromatography; (C) concentrating a CMPB-containing fraction; and (D) dissolving the thus-obtained CMPB-containing concentrate in an ether solvent and adding a hydrocarbon solvent to the resulting solution to precipitate CMPB crystals.
Public/Granted literature
- US20060293516A1 Penicillin crystal and process for producing the same Public/Granted day:2006-12-28
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