Invention Grant
- Patent Title: Process for the preparation of pyridylcarboxylic amides and esters
- Patent Title (中): 制备吡啶基羧酸酰胺和酯的方法
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Application No.: US12092021Application Date: 2006-10-26
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Publication No.: US07692020B2Publication Date: 2010-04-06
- Inventor: Monika Brink , Marcus Knell , Jan Hendrik Wevers
- Applicant: Monika Brink , Marcus Knell , Jan Hendrik Wevers
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Brinks Hofer Gilson & Lione
- International Application: PCT/EP2006/067818 WO 20061026
- International Announcement: WO2007/051759 WO 20070510
- Main IPC: C07D213/81
- IPC: C07D213/81

Abstract:
The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and R1 have the meanings given in claim 1, which comprises the following steps: (a) heating a mixture consisting essentially of trichloromethylpyridine II, Formula (II), wherein Hal has the meaning given, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, characterized in that the trichloromethylpyridine II in a liquid form is added to the concentrated sulfuric acid at a temperature from 110° C. to 160° C.; and (b) reacting the intermediate product obtained in step (a) with an amine or alcohol III, HXR1, wherein X and R1 have the meaning given, optionally in the presence of a solvent and/or a base.
Public/Granted literature
- US20080249313A1 Process for the Preparation of Pyridylcarboxylic Amides and Esters Public/Granted day:2008-10-09
Information query
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