Invention Grant
US07692034B2 Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
失效
通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法
- Patent Title: Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
- Patent Title (中): 通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法
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Application No.: US11657808Application Date: 2007-01-24
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Publication No.: US07692034B2Publication Date: 2010-04-06
- Inventor: Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
- Applicant: Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
- Applicant Address: IL Petah Tiqva
- Assignee: Teva Pharmaceutical Industries Ltd.
- Current Assignee: Teva Pharmaceutical Industries Ltd.
- Current Assignee Address: IL Petah Tiqva
- Agent Tyler A. Stevenson
- Priority: EP01810670 20010706
- Main IPC: C07C229/00
- IPC: C07C229/00
Abstract:
The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
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