A shoe provides a suspended orthotic system that includes at least a contoured, three-dimensional chassis configured with a heel cup. The chassis provides the primary support and determines the shape and form of the shoe. The chassis receives a footbed, which includes a first material integrally formed with a second material, both materials operating to provide an orthotic benefit. A shoe sole includes a number of pods that are selectively arranged and coupled to the chassis to actively suspend the chassis and the footbed. The shoe can further include a dynamic arch support system that manually or automatically adjusts the arch region of the shoe. The shoe may be more comfortable, provide biomechanical advantages, be lighter, and be more stylish than traditional shoes.