An artist's paint box comprising: a substantially parallelepiped box having an interior chamber, combination hinged easel and cover, and storage compartment having a hinged cover; a removably replaceable palette matingly received within the chamber and having opposing cutouts substantially parallel to each other and another cutout transverse to the opposing cutouts, the opposing cutouts and the transverse cutout forming a substantially U shape, a recessed paint color mixing area substantially centrally disposed between and adjacent the opposing cutouts and adjacent the transverse cutout, and a recessed paintbrush and tool holding area adjacent the transverse cutout and opposing the recessed paint color mixing area; removably replaceable paint wells removably and matingly received within the opposing cutouts and the transverse cutout, each of the removably replaceable paint wells having exteriorly disposed opposing side ridges resting on opposing edges adjacent each of the opposing cutouts and other opposing edges adjacent the transverse cutout.