Invention Grant
US07695908B2 Methods for predicting methotrexate polyglutamate levels using pharmacogenetics
有权
使用药物遗传学预测甲氨蝶呤聚谷氨酸水平的方法
- Patent Title: Methods for predicting methotrexate polyglutamate levels using pharmacogenetics
- Patent Title (中): 使用药物遗传学预测甲氨蝶呤聚谷氨酸水平的方法
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Application No.: US11152128Application Date: 2005-06-13
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Publication No.: US07695908B2Publication Date: 2010-04-13
- Inventor: Thierry Dervieux
- Applicant: Thierry Dervieux
- Applicant Address: US CA San Diego
- Assignee: Prometheus Laboratories Inc.
- Current Assignee: Prometheus Laboratories Inc.
- Current Assignee Address: US CA San Diego
- Agency: Cooley Godward Kronish LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention provides methods for determining a level of methotrexate polyglutamates (MTXPGs) in an individual undergoing methotrexate (MTX) therapy and for optimizing dose efficacy of MTX therapy in an individual by genotyping the individual at a polymorphic site in at least one folate pathway gene (e.g., a reduced folate carrier (RFC-1) gene, a gamma glutamyl hydrolase (GGH) gene, etc.). Methods are also provided for determining a level of MTXPGs in an individual undergoing MTX therapy and for optimizing dose efficacy of MTX therapy in an individual by generating a pharmacogenetic index based upon the genotype of the individual at a polymorphic site in an RFC-1 gene and/or a GGH gene.
Public/Granted literature
- US20060057609A1 Methods for predicting methotrexate polyglutamate levels using pharmacogenetics Public/Granted day:2006-03-16
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