Invention Grant
US07695920B2 Methods of screening compounds binding to presynaptic protein CAST
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筛选与突触前蛋白CAST结合的化合物的方法
- Patent Title: Methods of screening compounds binding to presynaptic protein CAST
- Patent Title (中): 筛选与突触前蛋白CAST结合的化合物的方法
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Application No.: US11979099Application Date: 2007-10-31
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Publication No.: US07695920B2Publication Date: 2010-04-13
- Inventor: Toshihisa Ohtsuka , Etsuko Rikitsu , Marie Inoue , Eiji Inoue
- Applicant: Toshihisa Ohtsuka , Etsuko Rikitsu , Marie Inoue , Eiji Inoue
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd
- Current Assignee: Eisai R&D Management Co., Ltd
- Current Assignee Address: JP Tokyo
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: JP2002-063186 20020308
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/567 ; G01N33/566 ; C07K1/00 ; C12P21/06
Abstract:
The present invention enabled the detection and quantification of CAST, which is localized to synapses and tightly bound to the cytomatrix, and of the mRNA encoding the CAST. Furthermore, it was revealed that CAST functions as a protein scaffold for localizing RIM1 to synapses, contributing as a molecular basis for active zone formation.
Public/Granted literature
- US20090087842A1 Presynaptic protein cast Public/Granted day:2009-04-02
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