Invention Grant
US07695943B2 Method for preparing 1,3-propanediol by a recombinant micro-organism in the absence of coenzyme B12 or one of its precursors
有权
在不存在辅酶B12或其前体之一时由重组微生物制备1,3-丙二醇的方法
- Patent Title: Method for preparing 1,3-propanediol by a recombinant micro-organism in the absence of coenzyme B12 or one of its precursors
- Patent Title (中): 在不存在辅酶B12或其前体之一时由重组微生物制备1,3-丙二醇的方法
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Application No.: US11839455Application Date: 2007-08-15
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Publication No.: US07695943B2Publication Date: 2010-04-13
- Inventor: Patricia Sarcabal , Christian Croux , Philippe Soucaille
- Applicant: Patricia Sarcabal , Christian Croux , Philippe Soucaille
- Applicant Address: FR Paris Cedex FR Toulouse Cedex FR Paris Cedex
- Assignee: Institut National de la Recherche,Institut National des Sciences,Centre National de la Recherche
- Current Assignee: Institut National de la Recherche,Institut National des Sciences,Centre National de la Recherche
- Current Assignee Address: FR Paris Cedex FR Toulouse Cedex FR Paris Cedex
- Agency: Fulbright & Jaworski LLP
- Main IPC: C12P7/02
- IPC: C12P7/02 ; C12N9/00 ; C12N9/88 ; C12N1/20 ; C07H21/04
Abstract:
The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursors. The invention also concerns a nucleic acid coding for a glycerol dehydratase whereof the catalytic activity is independent of the presence of coenzyme B12 or one of its precursors and a nucleic acid coding for a 1,3-propanol dehydrogenase intervening in the synthesis of 1,3-propanediol. The invention further concerns recombinant vectors and host cells comprising said nucleic acids and the polypeptides coded by the latter.
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