Invention Grant
- Patent Title: Antibodies that bind TNF-α converting enzyme
- Patent Title (中): 结合TNF-α转化酶的抗体
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Application No.: US11709436Application Date: 2007-02-21
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Publication No.: US07695948B2Publication Date: 2010-04-13
- Inventor: Roy A. Black , Charles Rauch , Carl J. March , Douglas P. Cerretti
- Applicant: Roy A. Black , Charles Rauch , Carl J. March , Douglas P. Cerretti
- Applicant Address: US CA Thousand Oaks
- Assignee: Immunex Corporation
- Current Assignee: Immunex Corporation
- Current Assignee Address: US CA Thousand Oaks
- Agent Susan E. Lingenfelter
- Main IPC: C12N9/48
- IPC: C12N9/48
Abstract:
A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
Public/Granted literature
- US20080160571A1 Antibodies that bind TNF-alpha converting enzyme Public/Granted day:2008-07-03
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