Invention Grant
- Patent Title: Methods for generating hypermutable microbes
- Patent Title (中): 产生超可变微生物的方法
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Application No.: US11360995Application Date: 2006-02-24
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Publication No.: US07695969B2Publication Date: 2010-04-13
- Inventor: Nicholas C. Nicolaides , Philip M. Sass , Luigi Grasso , Bert Vogelstein , Kenneth W. Kinzler
- Applicant: Nicholas C. Nicolaides , Philip M. Sass , Luigi Grasso , Bert Vogelstein , Kenneth W. Kinzler
- Applicant Address: US MD Baltimore US PA Philadelphia
- Assignee: The Johns Hopkins University,Morphotek, Inc.
- Current Assignee: The Johns Hopkins University,Morphotek, Inc.
- Current Assignee Address: US MD Baltimore US PA Philadelphia
- Agency: Banner & Witcoff, Ltd
- Main IPC: C12N15/74
- IPC: C12N15/74 ; C12N1/21
Abstract:
Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficiency and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch repair activity to the bacteria.
Public/Granted literature
- US20060194236A1 Methods for generating hypermutable microbes Public/Granted day:2006-08-31
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