Invention Grant
US07696169B2 Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
失效
HMGB多肽和toll样受体2之间的相互作用的抑制剂作为抗炎剂
- Patent Title: Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
- Patent Title (中): HMGB多肽和toll样受体2之间的相互作用的抑制剂作为抗炎剂
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Application No.: US11787032Application Date: 2007-04-13
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Publication No.: US07696169B2Publication Date: 2010-04-13
- Inventor: Kevin J. Tracey , Huan Yang
- Applicant: Kevin J. Tracey , Huan Yang
- Applicant Address: US NY Manhasset
- Assignee: The Feinstein Institute for Medical Research
- Current Assignee: The Feinstein Institute for Medical Research
- Current Assignee Address: US NY Manhasset
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K49/00
Abstract:
The invention features a method of treating an inflammatory condition in an individual, comprising administering an agent inhibits the interaction between a Toll-like receptor 2 (TLR2) and a high mobility group B (HMGB) polypeptide to the individual. The invention also features methods for identifying agents that inhibit the interaction between TLR2 and HMGB.
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