Invention Grant
- Patent Title: 16Alpha-methyl or ethyl substituted estrogens
- Patent Title (中): 16α-甲基或乙基取代的雌激素
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Application No.: US10343293Application Date: 2001-07-23
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Publication No.: US07696190B2Publication Date: 2010-04-13
- Inventor: Jordi Mestres , Hubert Jan Jozef Loozen , Gerrit Herman Veeneman
- Applicant: Jordi Mestres , Hubert Jan Jozef Loozen , Gerrit Herman Veeneman
- Applicant Address: NL Oss
- Assignee: N.V. Organon
- Current Assignee: N.V. Organon
- Current Assignee Address: NL Oss
- Agent Susan Hess
- Priority: EP00202697 20000728
- International Application: PCT/EP01/08535 WO 20010723
- International Announcement: WO02/10188 WO 20020207
- Main IPC: A61K31/56
- IPC: A61K31/56 ; C07J1/00 ; C07J7/00
Abstract:
The invention makes a 16α-substituted steroidal compound available having formula 1, wherein the dotted ring is a fully saturated, a fully aromatic or a saturated ring with a Δ5-10 double bond; R1 is (C1-C3)alkyl or (C2-C3)alkenyl, and each of these groups can be substituted with one or more halogens; R2 is (C1-C4;)alkyl, (C2-C4)alkenyl or methylene, and each of these groups can be substituted with one or more halogens; R3 is methyl or ethyl; or a prodrug thereof, which compound can be used for an estrogen receptor α selective treatment
Public/Granted literature
- US20040043976A1 16Alpha-methyl or ethyl substituted estrogens Public/Granted day:2004-03-04
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