Invention Grant
- Patent Title: Tricyclic anilide spirolactam CGRP receptor antagonists
- Patent Title (中): 三环苯胺己内酰胺CGRP受体拮抗剂
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Application No.: US11662246Application Date: 2005-09-06
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Publication No.: US07696192B2Publication Date: 2010-04-13
- Inventor: Ian M. Bell , Steven N. Gallicchio , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
- Applicant: Ian M. Bell , Steven N. Gallicchio , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent William Krovatin; John C. Todaro
- International Application: PCT/US2005/031617 WO 20050906
- International Announcement: WO2006/031491 WO 20060323
- Main IPC: A61K31/554
- IPC: A61K31/554
Abstract:
The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Public/Granted literature
- US20080214511A1 Tricyclic Anilide Spirolactam Cgrp Receptor Antagonists Public/Granted day:2008-09-04
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