Invention Grant
- Patent Title: Phosphodiesterase 4 inhibitors
- Patent Title (中): 磷酸二酯酶4抑制剂
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Application No.: US10825610Application Date: 2004-04-16
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Publication No.: US07696198B2Publication Date: 2010-04-13
- Inventor: Ashok Tehim , Allen Hopper , Ruiping Liu , Erik Kuester , Robert F. Dunn , Thomas E. Renau
- Applicant: Ashok Tehim , Allen Hopper , Ruiping Liu , Erik Kuester , Robert F. Dunn , Thomas E. Renau
- Applicant Address: US NJ Montvale
- Assignee: Memory Pharmaceuticals Corporation
- Current Assignee: Memory Pharmaceuticals Corporation
- Current Assignee Address: US NJ Montvale
- Agency: Millen, White, Zelano, Branigan, P.C.
- Main IPC: A61K31/54
- IPC: A61K31/54 ; A61K31/425 ; C07D417/02 ; C07D413/02 ; C07D405/00
Abstract:
Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein.
Public/Granted literature
- US20050026913A1 Phosphodiesterase 4 inhibitors Public/Granted day:2005-02-03
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