Invention Grant
US07696209B2 CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
有权
CGRP拮抗剂，其制备方法及其作为药物组合物的用途
- Patent Title: CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
- Patent Title (中): CGRP拮抗剂，其制备方法及其作为药物组合物的用途
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Application No.: US12363175Application Date: 2009-01-30
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Publication No.: US07696209B2Publication Date: 2010-04-13
- Inventor: Stephan Georg Mueller , Klaus Rudolf , Philipp Lustenberger , Dirk Stenkamp , Marco Santagostino , Fabio Paleari , Henri Doods , Kirsten Arndt , Gerhard Schaenzle
- Applicant: Stephan Georg Mueller , Klaus Rudolf , Philipp Lustenberger , Dirk Stenkamp , Marco Santagostino , Fabio Paleari , Henri Doods , Kirsten Arndt , Gerhard Schaenzle
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Mary-Ellen M. Devlin; Alan R. Stempel
- Priority: AR050101139 20050323; PE000336-2005/OIN 20050323; EP05021283 20050929
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/45 ; A61P25/06 ; A61P5/50
Abstract:
The present invention relates to the CGRP-antagonists of general formula I wherein R1, R2, R3, R4 and X are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, mixtures and salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I in which one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
Public/Granted literature
- US20090186881A1 CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions Public/Granted day:2009-07-23
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