Invention Grant
- Patent Title: Phenylurea derivatives as inhibitors of tyrosine kinases for the treatment of tumour diseases
- Patent Title (中): 苯脲衍生物作为治疗肿瘤疾病的酪氨酸激酶抑制剂
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Application No.: US11665183Application Date: 2005-09-16
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Publication No.: US07696224B2Publication Date: 2010-04-13
- Inventor: Wolfgang Staehle , Guenter Hoelzemann , Wilfried Rautenberg
- Applicant: Wolfgang Staehle , Guenter Hoelzemann , Wilfried Rautenberg
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Arent Fox LLP
- Priority: EP04024368 20041013
- International Application: PCT/EP2005/009983 WO 20050916
- International Announcement: WO2006/042599 WO 20060427
- Main IPC: A61K31/437
- IPC: A61K31/437 ; C07D471/04 ; A61P35/04
Abstract:
Compounds of the formula (I), in which R1a—R1e, R2a, R2b, R3 and X have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
Public/Granted literature
- US20080207682A1 Phenylurea Derivatives As Inhibitors Of Tyrosine Kinases For The Treatment Of Tumour Diseases Public/Granted day:2008-08-28
Information query
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