Invention Grant
US07696231B2 Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs)
失效
蛋白酪氨酸磷酸酶（PTPs）的羟吲哚酰肼调节剂
- Patent Title: Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs)
- Patent Title (中): 蛋白酪氨酸磷酸酶（PTPs）的羟吲哚酰肼调节剂
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Application No.: US10493066Application Date: 2002-10-24
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Publication No.: US07696231B2Publication Date: 2010-04-13
- Inventor: Agnes Bombrun , Patrick Gerber , Denis Church
- Applicant: Agnes Bombrun , Patrick Gerber , Denis Church
- Applicant Address: CH Coinsins
- Assignee: Laboratoires Serono SA
- Current Assignee: Laboratoires Serono SA
- Current Assignee Address: CH Coinsins
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP01125380 20011030
- International Application: PCT/EP02/11919 WO 20021024
- International Announcement: WO03/037328 WO 20030508
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/404 ; C07D209/46
Abstract:
The present invention is related to the use of oxindole hydrazide derivatives of formula (I) for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of oxindole hydrazide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular of PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel oxindole hydrazide derivatives and method of preparation thereof.(I).
Public/Granted literature
- US20050043388A1 Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) Public/Granted day:2005-02-24
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