Invention Grant
US07696244B2 Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
有权
通过突变体CFTR增加离子迁移活性的化合物及其用途
- Patent Title: Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
- Patent Title (中): 通过突变体CFTR增加离子迁移活性的化合物及其用途
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Application No.: US10556195Application Date: 2004-05-14
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Publication No.: US07696244B2Publication Date: 2010-04-13
- Inventor: Alan Verkman , Luis J. V. Galietta , R. Kiplin Guy
- Applicant: Alan Verkman , Luis J. V. Galietta , R. Kiplin Guy
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis, LLP
- Agent Carol L. Francis
- International Application: PCT/US2004/015386 WO 20040514
- International Announcement: WO2004/110352 WO 20041223
- Main IPC: A61K31/38
- IPC: A61K31/38 ; A01N43/06 ; A01N43/12
Abstract:
The invention provides compositions, including pharmaceutical preparations, which comprise one or more substituted thiophene, benzofuran, pyrimidinetrione, dihydropyridine, tetrahydrocarbazol or anthraquinone compounds. The invention also features methods of use of such compositions in increasing activity of mutant-cystic fibrosis transmembrane conductance regulator protein in a cell, e.g. by increasing ion transport in a mutant-CFTR.
Public/Granted literature
- US20070265316A1 Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof Public/Granted day:2007-11-15
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