Invention Grant
- Patent Title: Fluorescent probe for zinc
- Patent Title (中): 锌荧光探针
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Application No.: US10767334Application Date: 2004-01-30
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Publication No.: US07696245B2Publication Date: 2010-04-13
- Inventor: Kensuke Komatsu , Tomoya Hirano , Kazuya Kikuchi , Tetsuo Nagano
- Applicant: Kensuke Komatsu , Tomoya Hirano , Kazuya Kikuchi , Tetsuo Nagano
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: Sekisui Medical Co., Ltd.,Tetsuo Nagano
- Current Assignee: Sekisui Medical Co., Ltd.,Tetsuo Nagano
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2003-089987 20030328
- Main IPC: A61K31/353
- IPC: A61K31/353 ; C07D311/80

Abstract:
A compound represented by the following general formula (IA) or (IB) or a salt thereof which specifically traps a zinc ion and emits fluorescence, and is useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by the following formula (A): wherein X1 to X4 represent a hydrogen atom, a 2-pyridylmethyl group, a 2-pyridylethyl group, a 2-methyl-6-pyridylmethyl group, or a 2-methyl-6-pyridylethyl group, provided that at least one is the group except a 2-pyridylmethyl group, and m and n represent 0 or 1, provided that they are not simultaneously 0; provided that R1 and R2 are not simultaneously hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group; and R7 represents a hydrogen atom or an alkyl group.
Public/Granted literature
- US20050037332A1 Fluorescent probe for zinc Public/Granted day:2005-02-17
Information query
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