Invention Grant
US07696246B2 Bicyclic androgen and progesterone receptor modulator compounds and methods
有权
双环雄激素和孕激素受体调节剂的化合物和方法
- Patent Title: Bicyclic androgen and progesterone receptor modulator compounds and methods
- Patent Title (中): 双环雄激素和孕激素受体调节剂的化合物和方法
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Application No.: US11165769Application Date: 2005-06-23
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Publication No.: US07696246B2Publication Date: 2010-04-13
- Inventor: Lin Zhi , Cornelis Arjan Van Oeveren , Esther Martinborough
- Applicant: Lin Zhi , Cornelis Arjan Van Oeveren , Esther Martinborough
- Applicant Address: US CA San Diego
- Assignee: Ligand Pharmaceuticals Incorporated
- Current Assignee: Ligand Pharmaceuticals Incorporated
- Current Assignee Address: US CA San Diego
- Agency: K & L Gates LLP
- Agent Stephanie Seidman; Frank J. Miskiel
- Main IPC: A61K31/352
- IPC: A61K31/352 ; C07D311/18
Abstract:
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
Public/Granted literature
- US20050288350A1 Bicyclic androgen and progesterone receptor modulator compounds and methods Public/Granted day:2005-12-29
Information query
