Invention Grant
US07696309B2 Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
有权
蛋白酶抗性突变体的基质细胞衍生因子-1在修复组织损伤
- Patent Title: Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
- Patent Title (中): 蛋白酶抗性突变体的基质细胞衍生因子-1在修复组织损伤
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Application No.: US11976032Application Date: 2007-10-19
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Publication No.: US07696309B2Publication Date: 2010-04-13
- Inventor: Richard Lee , Vincent Segers
- Applicant: Richard Lee , Vincent Segers
- Applicant Address: US MA Boston
- Assignee: The Brigham and Women's Hospital, Inc.
- Current Assignee: The Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/00
Abstract:
The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
Public/Granted literature
- US20080095758A1 Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage Public/Granted day:2008-04-24
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