Invention Grant
- Patent Title: Prodrug compounds with isoleucine
- Patent Title (中): 前药与异亮氨酸的化合物
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Application No.: US12009031Application Date: 2008-01-16
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Publication No.: US07696313B2Publication Date: 2010-04-13
- Inventor: Lesley B. Pickford , Sanjeev Gangwar , Thomas J. Lobl , Matthew H. Nieder , Geoffrey T. Yarranton
- Applicant: Lesley B. Pickford , Sanjeev Gangwar , Thomas J. Lobl , Matthew H. Nieder , Geoffrey T. Yarranton
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Lahive & Cockfield, LLP
- Agent Jane E. Remillard; Brian C. Trinque
- Main IPC: C07K1/113
- IPC: C07K1/113 ; C07K1/14
Abstract:
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of making and using the compounds are also disclosed.
Public/Granted literature
- US20080255248A1 Prodrug compounds with isoleucine Public/Granted day:2008-10-16
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