Invention Grant
- Patent Title: Polypeptide inducing apoptosis
- Patent Title (中): 多肽诱导细胞凋亡
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Application No.: US10221131Application Date: 2001-03-12
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Publication No.: US07696325B2Publication Date: 2010-04-13
- Inventor: Naoshi Fukushima , Masayuki Tsuchiya , Masayoshi Oh-Eda , Shinsuke Uno , Yasufumi Kikuchi
- Applicant: Naoshi Fukushima , Masayuki Tsuchiya , Masayoshi Oh-Eda , Shinsuke Uno , Yasufumi Kikuchi
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Foley & Lardner LLP
- Priority: JP2000-115246 20000417; JP2000-321822 20001020
- International Application: PCT/JP01/01912 WO 20010312
- International Announcement: WO01/66737 WO 20010913
- Main IPC: C07K16/00
- IPC: C07K16/00
Abstract:
This invention relates to reconstructed polypeptides which have properties of inducing apoptosis of nucleated blood cells having Integrin Associated Protein (IAP) and causing no hemagglutination. The reconstructed polypeptides comprise two or more H chain V regions and two or more L chain V regions of a monoclonal antibody which induces apoptosis of nucleated blood cells having IAP. The reconstructed polypeptides are useful as a therapeutic agent for blood dyscrasia such as leukemia.
Public/Granted literature
- US20040073013A1 Polypeptide inducing apoptosis Public/Granted day:2004-04-15
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