Invention Grant
US07696328B2 N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor
失效
N-苄氧羰基（N-CBZ） - 保护酶，并用于此
- Patent Title: N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor
- Patent Title (中): N-苄氧羰基（N-CBZ） - 保护酶，并用于此
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Application No.: US12150544Application Date: 2008-04-28
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Publication No.: US07696328B2Publication Date: 2010-04-13
- Inventor: Venkata B. Nanduri , Ramesh N. Patel , Steven L. Goldberg , Robert M. Johnston
- Applicant: Venkata B. Nanduri , Ramesh N. Patel , Steven L. Goldberg , Robert M. Johnston
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Nikki L. Parlet
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/40 ; C07K16/46 ; C07K14/00 ; C07K5/00
Abstract:
This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.
Public/Granted literature
- US20090104670A1 N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor Public/Granted day:2009-04-23
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