Invention Grant
US07696365B2 Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors
失效
可用作丙二酰辅酶A脱羧酶抑制剂的杂环化合物
- Patent Title: Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors
- Patent Title (中): 可用作丙二酰辅酶A脱羧酶抑制剂的杂环化合物
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Application No.: US10900958Application Date: 2004-07-28
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Publication No.: US07696365B2Publication Date: 2010-04-13
- Inventor: Jie Fei Cheng , Bao Ngoc Nguyen , Xuewei Liu , Gary D. Lopaschuk , Jason R. Dyck
- Applicant: Jie Fei Cheng , Bao Ngoc Nguyen , Xuewei Liu , Gary D. Lopaschuk , Jason R. Dyck
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Main IPC: C07D307/00
- IPC: C07D307/00
Abstract:
The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
Public/Granted literature
- US20050026969A1 Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors Public/Granted day:2005-02-03
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