A framework structure for a computer main frame, comprises an outer frame and an inner frame in which the inner frame is combined with an inner portion of the outer frame. A rear end of a first plate is pivotally connected to a bottom of the inner frame, and a front end of the first plate is combined with a downside of a bottom of the inner frame and positioned on a downside of a first hole of the inner frame. A hard drive can be locked on an upside of the first plate. Bottom ends of a plurality of shafts are respectively combined with the inner frame so as to use upper ends of the shafts to combine with a motherboard to allow the hard drive to be positioned below the motherboard.