A system and method to reduce standby leakage current in the event of row-to-column shorts in a memory chip or in an electronic device having memory or data storage elements is disclosed. In case of memory rows or wordlines precharged to a negative wordline voltage (VNWL), the standby leakage current through Psense-amplifiers in the memory is substantially eliminated when the gates of isolation (ISO) transistors associated with the shorted wordline and digitline(s) are held at the VNWL level by an isolation signal driven to the VNWL level during the memory row standby state. The reduction in the standby leakage current further reduces the overall Icc current consumption from the memory circuit's supply or operating voltage Vcc, thereby reducing circuit's standby power consumption. Because the ISO gates are already fabricated with thick oxides, the present negative voltage driving methodology does not require modifying the sense amplifier layout or the configuration of existing isolation transistors in a memory chip. A different standby voltage level (Vcc/2 level) at the sense amplifier activation (ACT) signal may also be implemented. Because of the rules governing abstracts, this abstract should not be used to construe the claims.