In a programmable logic device having a specialized functional block incorporating multipliers and adders, multiplication operations that do not fit neatly into the available multipliers are performed partially in the multipliers of the specialized functional block and partially in multipliers configured in programmable logic of the programmable logic device. Unused resources of the specialized functional block, including adders, may be used to add together the partial products produced inside and outside the specialized functional block. Some adders configured in programmable logic of the programmable logic device also may be used for that purpose.