A toothbrush with a head having at least one pair of twisted wire brushes secured to the head's top surface in a position that creates a narrow and substantially uniform trench between the bristles of opposing brushes. Head construction may be solid, curved, blunt, tapering, or have a forked distal end. When a user's brace hardware and/or orthodontic wires are placed within the trench, bristles adjacent to it reach tooth surfaces behind the orthodontic wires to gently remove plaque without wire or hardware breakage. The twisted wires of opposing conical brushes are not parallel so as to create a uniform trench. The twisted wires in narrow end of conical brushes are also angled toward the distal end of the toothbrush head to facilitate reaching crowded back teeth without orthodontic wire breakage. The toothbrush handle can be laterally angled relative to its head and brushes are optionally replaceable by the user.