Invention Grant
US07700629B2 Use of a non-racemic mixture of bupivacaine enantiomers, for improving the anesthesia profile
有权
使用布比卡因对映异构体的非外消旋混合物，以改善麻醉概况
- Patent Title: Use of a non-racemic mixture of bupivacaine enantiomers, for improving the anesthesia profile
- Patent Title (中): 使用布比卡因对映异构体的非外消旋混合物，以改善麻醉概况
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Application No.: US11806624Application Date: 2007-06-01
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Publication No.: US07700629B2Publication Date: 2010-04-20
- Inventor: Roberto T. Sudo , Valter F. T. Russo , Elisa M. S. Russo
- Applicant: Roberto T. Sudo , Valter F. T. Russo , Elisa M. S. Russo
- Applicant Address: BR Sao Paulo
- Assignee: Cristalia Productos Quimicos Farmaceuticos Ltda
- Current Assignee: Cristalia Productos Quimicos Farmaceuticos Ltda
- Current Assignee Address: BR Sao Paulo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: BR0002246 20000406
- Main IPC: A61K31/4458
- IPC: A61K31/4458 ; C07D211/32
Abstract:
The present invention describes a new method for the separation of bupivacaine enantiomers consisting in a continuous separation process performed without heating, by the selective precipitation of their diastereomeric salts with tartaric acid. This heatless process avoids the degradation of the reagents granting a continuous process feature to the procedure.Another embodiment of the present invention is related to the enantiomeric manipulation of bupivacaine enantiomers in order to obtain pharmaceutical compositions presenting several enantiomeric excess of levobupivacaine to quantify and determinate the role of the dextrobupivacaine on its anesthetic and cardiotoxic effects. These enantiomeric manipulated compositions showed to present an expressive improvement on its anesthetic properties that had shown to be similar to racemic bupivacaine presenting a cardiotoxic profile similar to enantiomeric pure levobupivacaine.
Public/Granted literature
- US20070249681A1 Bupivacaines Public/Granted day:2007-10-25
Information query
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