Invention Grant
- Patent Title: Factor VII or VIIa polypeptide variants
- Patent Title (中): 因子VII或VIIa多肽变体
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Application No.: US10512754Application Date: 2003-04-29
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Publication No.: US07700733B2Publication Date: 2010-04-20
- Inventor: Jesper Mortensen Haaning , Kim Vilbour Andersen
- Applicant: Jesper Mortensen Haaning , Kim Vilbour Andersen
- Applicant Address: US NY Tarrytown
- Assignee: Bayer HealthCare LLC
- Current Assignee: Bayer HealthCare LLC
- Current Assignee Address: US NY Tarrytown
- Agent Fernando I. Santos, Jr.
- International Application: PCT/DK03/00276 WO 20030429
- International Announcement: WO03/093465 WO 20031113
- Main IPC: A61K35/14
- IPC: A61K35/14
Abstract:
The present invention relates to novel polypeptide variants of factor VII (FVII) or factor VIIa (FVIIa) polypeptides, where said variants comprise an amino acid substitution in position 10 and 32 and where said variants further comprise a sugar moiety covalently attached to an introduced in vivo N-glycosylation site located outside the Gla domain. Such polypeptide variants are useful in therapy, in particular for the treatment of a variety of coagulation-related disorders, such as trauma.
Public/Granted literature
- US20060111282A1 Factor vii or viia polypeptide variants Public/Granted day:2006-05-25
Information query
IPC分类:
