Invention Grant
- Patent Title: Recombinant human metapneumovirus and its use
- Patent Title (中): 重组人间质肺病毒及其用途
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Application No.: US10789400Application Date: 2004-02-27
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Publication No.: US07704491B2Publication Date: 2010-04-27
- Inventor: Peter L. Collins , Stephane Biacchesi , Ursula Buchholz , Mario H. Skiadopoulos , Brian R. Murphy
- Applicant: Peter L. Collins , Stephane Biacchesi , Ursula Buchholz , Mario H. Skiadopoulos , Brian R. Murphy
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Woodcock Washburn LLP
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K39/12 ; A61K39/155
Abstract:
Recombinant HMPV (rHMPV) and related immunogenic compositions and methods are provided. The rHMPVs, including chimeric and chimeric HMPV vectors viruses, provided according to the current disclosure are infectious and attenuated in permissive mammalian subjects, including humans. The rHMPVs are useful in immunogenic compositions for eliciting an immune response against HPIV, against one or more non-HMPV pathogens, or against a HMPV and a non-HMPV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HMPV genome or antigenome.
Public/Granted literature
- US20040241188A1 Recombinant human metapneumovirus and its use Public/Granted day:2004-12-02
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