Invention Grant
US07704961B2 Avermectins and avermectin monosacharides substituted in the 4′-and 4″ position having pesticidal properties
有权
在具有杀虫性的4'和4“位置取代的阿维菌素和阿维菌素单糖苷
- Patent Title: Avermectins and avermectin monosacharides substituted in the 4′-and 4″ position having pesticidal properties
- Patent Title (中): 在具有杀虫性的4'和4“位置取代的阿维菌素和阿维菌素单糖苷
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Application No.: US10568715Application Date: 2004-08-27
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Publication No.: US07704961B2Publication Date: 2010-04-27
- Inventor: Fiona Murphy Kessabi , Thomas Pitterna , Peter Maienfisch , Jérôme Cassayre , Laura Quaranta , Pierre Jung , Ottmar Franz Hueter
- Applicant: Fiona Murphy Kessabi , Thomas Pitterna , Peter Maienfisch , Jérôme Cassayre , Laura Quaranta , Pierre Jung , Ottmar Franz Hueter
- Applicant Address: US GA Duluth
- Assignee: Merial Limited
- Current Assignee: Merial Limited
- Current Assignee Address: US GA Duluth
- Agency: Merial Limited
- Agent Judy Jarecki-Black; Thomas Kowalski, Esq.
- Priority: GB0320176.1 20030828
- International Application: PCT/EP2004/009594 WO 20040827
- International Announcement: WO2005/021569 WO 20050310
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A61K31/7028 ; C07H17/08
Abstract:
Described is a compound of the formula (I) wherein the bond between carbon atoms 22 and 23 is a single or double bond; m is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and either (A) R2 is —N(R3)R4, and (1) X is 0, wherein R3 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl, and R4 is, for instance, mono- to pentasubstituted C1-C12alkyl, unsubstituted or mono- to pentasubstituted C3-C12cycloalkyl; or (2) X is S, wherein R3 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl, and R4 is, for instance, hydrogen, unsubstituted or mono- to pentasubstituted C1-C12alkyl; or (3) X is 0 or S, wherein R3 and R4 together are, for instance, a three- to seven membered alkylene or a four- to seven-membered alkenylene bridge; or (B) R2 is OR5, X is 0 or S, wherein R5 is, for instance, C1-C12alkyl, mono- to pentasubstituted C1-C12alkyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof, in each case in free form or in salt form; such a compound demonstrates pesticidal activity.
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