Invention Grant
- Patent Title: Methods and compounds for the targeting of protein to exosomes
- Patent Title (中): 用于将蛋白质靶向外来体的方法和化合物
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Application No.: US10485360Application Date: 2002-08-14
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Publication No.: US07704964B2Publication Date: 2010-04-27
- Inventor: Alain Delcayre , Jean-Bernard Le Pecq
- Applicant: Alain Delcayre , Jean-Bernard Le Pecq
- Applicant Address: US CA Menlo Park
- Assignee: Exothera L.L.C.
- Current Assignee: Exothera L.L.C.
- Current Assignee Address: US CA Menlo Park
- Agency: Nixon & Vanderhye P.C.
- International Application: PCT/EP02/09108 WO 20020814
- International Announcement: WO03/016522 WO 20030227
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C12N15/74 ; C12N15/09 ; A61N63/00

Abstract:
The present invention relates to compositions and methods for selectively expressing a polypeptide in a membrane vesicle. The invention also relates to genetic constructs and recombinant cells suitable to produce such membrane vesicles. This invention also relates to such functionalized membrane vesicles as well as to methods of making antibodies, methods of producing or regulating an immune response as well as to methods of screening or identifying binding partners using the same. The invention more particularly uses lactadherin or portions thereof to selectively express polypeptides in membrane vesicles, of natural or synthetic origin. This invention can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.
Public/Granted literature
- US20040197314A1 Methods and compounds for the targeting of protein to exosomes Public/Granted day:2004-10-07
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