Invention Grant
US07705003B2 Cyclohexylamides as dopamine D3, D2 and 5-HT1A Antagonists
失效
环己基酰胺作为多巴胺D3,D2和5-HT1A拮抗剂
- Patent Title: Cyclohexylamides as dopamine D3, D2 and 5-HT1A Antagonists
- Patent Title (中): 环己基酰胺作为多巴胺D3,D2和5-HT1A拮抗剂
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Application No.: US11814874Application Date: 2006-02-02
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Publication No.: US07705003B2Publication Date: 2010-04-27
- Inventor: Eva Againe Csongor , Janos Galambos , Istvan Gyertyan , Bela Kiss , Katalin Saghy , Eva Schmidt , Gyoergy Domany
- Applicant: Eva Againe Csongor , Janos Galambos , Istvan Gyertyan , Bela Kiss , Katalin Saghy , Eva Schmidt , Gyoergy Domany
- Applicant Address: HU Budapest
- Assignee: Richter Gedeon Vegyeszeti Gyar RT.
- Current Assignee: Richter Gedeon Vegyeszeti Gyar RT.
- Current Assignee Address: HU Budapest
- Agency: Darby & Darby, P.C.
- Priority: HU0500170 20050203
- International Application: PCT/HU2006/000012 WO 20060202
- International Announcement: WO2006/082456 WO 20060810
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; C07D241/04 ; C07D295/00

Abstract:
The present invention relates to new dopamine D3 and D2 and serotonin 5-HT1A receptor subtype preferring ligands of formula (I); wherein A represents alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or a group of formula —NR1R2, wherein R1 and R2 represent independently a substituent selected from hydrogen, alkyl, alkenyl, aryl, heteroaryl or cycloalkyl or R1 and R2 form with the adjacent nitrogen atom and optionally with further heteroatom(s) a heterocyclic ring; m is an integer of 0 to 1; n is an integer of 1 to 2, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates thereof, to the processes for producing the same, to pharmacological compositions containing the same and to their use in therapy and/or prevention of a condition which requires modulation of dopamine and/or 5-HT1A receptors.
Public/Granted literature
- US20080103140A1 Cyclohexylamides as Dopamine D3, D2 and 5Ht1a Antagonists Public/Granted day:2008-05-01
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