Invention Grant
- Patent Title: Indoline amide derivatives as EP4 receptor ligands
- Patent Title (中): 二氢吲哚衍生物作为EP4受体配体
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Application No.: US12227280Application Date: 2007-06-08
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Publication No.: US07705035B2Publication Date: 2010-04-27
- Inventor: Michael Boyd , John Colucci
- Applicant: Michael Boyd , John Colucci
- Applicant Address: CA Kirkland, Province of Quebec
- Assignee: Merck Frosst Canada Ltd.
- Current Assignee: Merck Frosst Canada Ltd.
- Current Assignee Address: CA Kirkland, Province of Quebec
- Agent Curtis C. Panzer; Valerie J. Camara
- International Application: PCT/CA2007/001028 WO 20070608
- International Announcement: WO2007/143825 WO 20071221
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D209/08 ; A61K31/404 ; A61K31/437
Abstract:
The invention is directed to indoline amide derivatives of formula I as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included.
Public/Granted literature
- US20090105321A1 Indole Amide Derivatives as Ep4 Receptot Ligands Public/Granted day:2009-04-23
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