A circuit for measuring respiratory waveform with impedance method and a method and device for resisting electrical fast transient interference are provided, and wherein an output from the peak detector circuit and a reference signal are input to two input terminals of the comparator circuit, an output terminal of the comparator circuit is connected to a control terminal of the electronic switch, and one terminal of the electronic switch is connected to an output terminal of the signal amplifier circuit and the other to an input terminal of the demodulator/amplifier circuit. If a level of the output signal of the peak detector circuit is greater than the level of the reference signal, the electronic switch is switched off in response to an inversion of the output of the comparator circuit so that the interference is isolated from the next stage circuit. The present invention is prone to be implemented with significant effect.