An improved total disc replacement system and related methods, wherein a pair of anchor plates, each adapted to engage a vertebral body, and a translating internal member are provided. The translating internal member boasts the ability to move or translate between the anchor plates without compromising the conformity of the interface between the translating internal member and the anchor plates. In a significant aspect, the anchor plates may be locked in place relative to one another after implantation to effect fusion between the vertebral bodies.