Invention Grant
US07708989B2 Methods of treating vascular diseases characterized by nitric oxide insufficiency
失效
治疗以一氧化氮不足为特征的血管疾病的方法
- Patent Title: Methods of treating vascular diseases characterized by nitric oxide insufficiency
- Patent Title (中): 治疗以一氧化氮不足为特征的血管疾病的方法
-
Application No.: US10692724Application Date: 2003-10-27
-
Publication No.: US07708989B2Publication Date: 2010-05-04
- Inventor: Joseph Loscalzo , Joseph A. Vita , Michael D. Loberg , Manuel Worcel
- Applicant: Joseph Loscalzo , Joseph A. Vita , Michael D. Loberg , Manuel Worcel
- Applicant Address: US NC Charlotte
- Assignee: NitroMed, Inc.
- Current Assignee: NitroMed, Inc.
- Current Assignee Address: US NC Charlotte
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: A61K38/43
- IPC: A61K38/43 ; A01N43/04

Abstract:
The invention provides methods of treating and/or preventing vascular diseases characterized by nitric oxide insufficiency by administering a therapeutically effective amount of at least one nitrosated angiotensin-converting enzyme inhibitor, nitrosated beta-adrenergic blocker, nitrosated cholesterol reducer, nitrosated calcium channel blocker, nitrosated endothelin antagonist, nitrosated angiotensin II receptor antagonist, nitrosated renin inhibitor, and optionally at least one compound used to treat cardiovascular diseases and/or at least one antioxidant, or a pharmaceutically acceptable salt thereof, and/or at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The antioxidant may preferably be a hydralazine compound or a pharmaceutically acceptable salt thereof. The compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase may preferably be isosorbide dinitrate and/or isosorbide mononitrate. The vascular diseases characterized by nitric oxide insufficiency include a cardiovascular disease and a disease resulting from oxidative stress.
Public/Granted literature
- US20090226407A9 METHODS OF TREATING VASCULAR DISEASES CHARACTERIZED BY NITRIC OXIDE INSUFFICIENCY Public/Granted day:2009-09-10
Information query
IPC分类: