Invention Grant
- Patent Title: Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
- Patent Title (中): 从克隆的核苷酸序列产生减毒呼吸道合胞病毒疫苗
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Application No.: US10934003Application Date: 2004-09-02
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Publication No.: US07709007B2Publication Date: 2010-05-04
- Inventor: Brian R. Murphy , Peter L. Collins , Stephen S. Whitehead , Alexander A. Bukreyev , Katalin Juhasz , Michael N. Teng
- Applicant: Brian R. Murphy , Peter L. Collins , Stephen S. Whitehead , Alexander A. Bukreyev , Katalin Juhasz , Michael N. Teng
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Woodcock Washburn LLP
- Main IPC: A61K39/155
- IPC: A61K39/155

Abstract:
Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.
Public/Granted literature
- US20060159703A1 Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences Public/Granted day:2006-07-20
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