Invention Grant
- Patent Title: Influenza A virus vaccines and inhibitors
- Patent Title (中): 甲型流感病毒疫苗和抑制剂
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Application No.: US11566216Application Date: 2006-12-02
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Publication No.: US07709190B2Publication Date: 2010-05-04
- Inventor: Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
- Applicant: Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Chalker Flores, LLP
- Agent Edwin S. Flores; Chainey P. Singleton
- Main IPC: C12Q1/70
- IPC: C12Q1/70
Abstract:
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
Public/Granted literature
- US20080108050A1 INFLUENZA A VIRUS VACCINES AND INHIBITORS Public/Granted day:2008-05-08
Information query
