Invention Grant
US07709216B2 Methods for preventing or reducing ischemia/reperfusion induced myocardial cell death
失效
预防或减少缺血/再灌注诱导心肌细胞死亡的方法
- Patent Title: Methods for preventing or reducing ischemia/reperfusion induced myocardial cell death
- Patent Title (中): 预防或减少缺血/再灌注诱导心肌细胞死亡的方法
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Application No.: US11891015Application Date: 2007-08-08
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Publication No.: US07709216B2Publication Date: 2010-05-04
- Inventor: Peter Erhardt , Ambrus Toth
- Applicant: Peter Erhardt , Ambrus Toth
- Applicant Address: US MA Watertown
- Assignee: Boston Biomedical Research Institute
- Current Assignee: Boston Biomedical Research Institute
- Current Assignee Address: US MA Watertown
- Agency: Pierce Atwood LLP
- Agent Kevin M. Farrell; David J. Wilson
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
Provided herein are methods relating to inhibition of PUMA function for preventing or reducing myocardial cell death. A method for preventing or reducing ischemia/reperfusion induced myocardial cell death in a human is provided as are methods for identifying pharmaceuticals which interfere with PUMA function. Also herein provided is a method for reducing stem cell death in stem cell explants wherein the explants are intended to restore cardiac efficiency following cell death in response to coronary infarct.
Public/Granted literature
- US20080009030A1 Methods for preventing or reducing ischemia/reperfusion induced myocardial cell death Public/Granted day:2008-01-10
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