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US07709444B2 Echinocandin pharmaceutical formulations containing micelle-forming surfactants 有权
含有胶束形成表面活性剂的棘白菌素药物制剂

Echinocandin pharmaceutical formulations containing micelle-forming surfactants
Abstract:
Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.
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