Invention Grant
US07709444B2 Echinocandin pharmaceutical formulations containing micelle-forming surfactants
有权
含有胶束形成表面活性剂的棘白菌素药物制剂
- Patent Title: Echinocandin pharmaceutical formulations containing micelle-forming surfactants
- Patent Title (中): 含有胶束形成表面活性剂的棘白菌素药物制剂
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Application No.: US11103798Application Date: 2005-04-11
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Publication No.: US07709444B2Publication Date: 2010-05-04
- Inventor: Nathaniel Milton , Kenneth Philip Moder , James Lawrence Sabatowski , Stephanie Ann Sweetana
- Applicant: Nathaniel Milton , Kenneth Philip Moder , James Lawrence Sabatowski , Stephanie Ann Sweetana
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent Gregg C. Benson; Jason Tebbutt
- Main IPC: A61K38/12
- IPC: A61K38/12

Abstract:
Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.
Public/Granted literature
- US20050192213A1 Echinocandin pharmaceutical formulations containing micelle-forming surfactants Public/Granted day:2005-09-01
Information query
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